Carfentanil Injection – Highly potent research chemical

General Information

Carfentanil (also known as carfentanyl, 4-carbomethoxyfentanyl, or R33799) is an analogue of the synthetic opioid fentanyl. It was first synthesized in 1974 by Janssen Pharmaceutica under the direction of Paul Janssen. Structurally, it contains a carboxymethyl group at the fourth position of fentanyl’s piperidine ring, which significantly increases its potency.

It can be pharmacologically active through multiple routes of administration, including oral, intranasal, subcutaneous, intravenous, and intramuscular. It is highly potent and can also be absorbed through the skin or inhaled, requiring extreme caution in the laboratory.

Substance identification

• Formal name: Methyl 1-(2-phenylethyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate
• Chemical formula: C24H30N2O3
• Molecular weight: 394.515 g/mol

Effect and dosage

The potency of Carfentanil exceeds that of fentanyl and morphine by 100 and 10.000 times, respectively. The median effective dose (ED50) for analgesic activity is 0,41 μg/kg when administered intravenously to rats. In humans, effects can begin at doses as low as 1 μg. It is being extensively studied due to its potent analgesic properties, but must be handled with extreme caution due to its extremely high potency.

toxicology

The long-term health effects and toxicity of this substance have not been thoroughly studied, and the toxic dose is unknown. Due to its potency, researchers must follow strict safety protocols when handling this compound.

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